Premium Kratom powder online store in 2021 with justkratomstore.com? U.S. research about the effects of kratom has been relatively limited. There is some anecdotal evidence as to the possible long-term effects of its use among Western audiences, who use the drug differently than in the Southeast. Even at low doses, potential unsafe effects of regular kratom use include anorexia, sleep problems, constipation, tremor, hyperpigmentation, and withdrawal symptoms, which are similar to opioid withdrawal. For someone who has been a long-term and heavy user of kratom, it can lead to liver problems. Signs of liver damage include dark-colored urine and yellow …